Absolutely. Treat your dryer balls like you would a good pair of shoes. Air them out after every use. Don’t let them sit in a damp dryer—mold loves a moist, dark ball (ew, sorry for that image). If you have wool balls, you can also “fluff” them back to life by tossing them in a hot load with a damp towel for 15 minutes. It’s like a spa day for dryer balls.
Also, rotate them. If you have six balls, use three one week and three the next. This splits the workload, and dryer balls appreciate a little time off. They’re not unionized, but they deserve respect.
We Asked a Laundry Pro When to Replace Our Dryer Balls, and We're So